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Enzymes and Their Inhibitors: Drug Development

Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise;

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Enzymes and Their Inhibitors: Drug Development

Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise;

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Evaluation of Enzyme Inhibitors in Drug Discovery

With enzymes being the most valued and common of drug targets, an understanding of their interactions with inhibitors is critical to;

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Kinase Inhibitors

of these enzymes and their misregulation has been shown to be involved in the onset and progression of many diseases including cancer and;

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Kinase Inhibitors

of these enzymes and their misregulation has been shown to be involved in the onset and progression of many diseases including cancer and;

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Kinetics of Enzyme Action

enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential;

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Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC;

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Phosphodiesterases and Their Inhibitors

(PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE;

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Proteinase and Peptidase Inhibition

. The target enzymes themselves, together with all aspects of their inhibition and inhibitor design, are comprehensively described. The;

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Oxidative Stress in Heart Diseases

studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling;

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Proteases as Targets for Therapy

This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human;

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Alpha-glucosidase Inhibitors

can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer;

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DNA Repair in Cancer Therapy

are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for;

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Proteinases as Drug Targets

This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for;

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Protease Inhibitors in AIDS Therapy

of revolutionary drugs fighting against HIV infection and AIDS, this comprehensive reference thoroughly examines the development and properties of HIV;

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Phosphodiesterases as Drug Targets

, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development;

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Drug Development

In this book, the authors discuss the principles, methodology and emerging challenges of drug development. Topics include outsourcing and;

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Human Immunodeficiency Virus Reverse Transcriptase

involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage;

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Enzyme Inhibition in Drug Discovery and Development

This book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both;

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Enzymes & Enzyme Activity

action; the myeloperoxidase enzyme as a diagnostic biomarker and target for new drug developments; the biological effects of calpain inhibitors;

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Targeted Therapies in Cancer

century has seen the emergence of targeted therapy, resulting from the identification of molecular pathways in cells and their alterations;

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Lipid Signaling in Human Diseases

. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes;

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Lipid Signaling in Human Diseases

. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes;

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Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current;

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Third Generation EGFR Inhibitors

chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR;

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Structural Biology in Drug Discovery: Methods, Techniques, and Practices

, this book covers principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development;

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Polyamine Drug Discovery

metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes;

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