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manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post;
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This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly;
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. Significant damage may hinder the RNA transcription process as well as cause mutations in the DNA molecule. Cell aging, apoptosis and cancerous tumors;
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recessive and cancer-prone syndromes characterized by deficiencies in various DNA repair pathways. Realizing the importance of DNA repair;
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deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the;
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). In spite of confirmed OS in DM or IBD, the substantial information about the intensity of DNA repair and its possible relationship to the disease;
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Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details;
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, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA;
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of chromatin remodelling. As opposed to DNA repair, damage tolerance allows cells to replicate with lesions in the genome; the enzymes responsible are;
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of chromatin as an integrative indicator of cell stress; analysing DNA damage and its repair throughout entire genomes; the cloning process, structural;
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DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that;
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of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and;
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information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages;
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, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement;
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, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement;
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; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease;
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This book presents and discusses topical research in the study of DNA, genetics and cell biology. Topics discussed include DNA damage;
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DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the;
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This volume emphasizes the intracellular consequences of DNA damage, describing procedures for analysis of checkpoint responses, DNA repair;
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that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the;
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free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the;
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envisaging better therapies. This book brings to the foreground the key role DNA repair plays in human health and well-being. The chapters present;
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The maintenance of DNA integrity and genome stability is essential for the viability of cells and the life of organisms. The genetic;
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level, we need to know the type and frequency of DNA adducts within cells, their distribution along genes and specific DNA sequences, as well as;
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In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This;
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Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair;
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Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair;
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