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This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic;
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adaptive function of sex in bacteria and eukaryotes; DNA repair as a therapeutic target in breast cancer; DNA repair in the nervous system;
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recessive and cancer-prone syndromes characterized by deficiencies in various DNA repair pathways. Realizing the importance of DNA repair;
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Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details;
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, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA;
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DNA molecules undergo chemical reactions which may alter their structure and DNA repair is the process by which such damages are repaired;
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process directs the repair of many DNA lesions in somatic cells and generates genetic variation in sperm and egg cells during meiosis. It is a;
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DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference;
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A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The;
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, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA;
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of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the;
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of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the;
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DNA repair is a rapidly advancing field in biology. DNA repair systems represent a major defense mechanism against environmental and;
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In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This;
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role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a;
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molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote;
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DNA Repair, Part A provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the;
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information on DNA photolesions and repair, as well as the key mechanisms of solar UV in skin cancer initiation and development. Significant;
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independently discovered in the laboratories of Paul Mandel, Osamu Hayaishi and Takashi Sugimura, all whom contribute to ADP-Ribosylation, DNA Repair;
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DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that;
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in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, replication;
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biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors;
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Breast cancer is characterised by the accumulation of genetic alterations, including point mutations and loss of entire DNA regions ( loss;
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Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the;
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BRCA1 (breast cancer) OB (obese) and those involved in DNA repair. In addition the author covers the increase in gene therapy trials and the;
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, mutagenesis and cancer. The purpose of this book is to present an updated detailed account of some important additional diseases of DNA repair. It;
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reason for this is the revelation that the biochemical pathways for the accurate replication, repair and recombination of DNA have been conserved;
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