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Target Discovery and Validation

Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and;

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Molecular Cancer Therapeutics

for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters;

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In Silico Technologies in Drug Target Identification and Validation

and practical guide to the various computational tools that can accelerate the identification and validation stages of drug target discovery;

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Handbook of Drug Screening

chapters, this text examines: quality and efficiency of drug target validation and potential drug compound selection reducing;

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Imaging in Drug Discovery and Early Clinical Trials

This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target;

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Molecular Targets in Protein Misfolding and Neurodegenerative Disease

, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation;

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Phenotypic Drug Discovery

and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using;

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Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry;

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Modern Approaches in Drug Discovery

field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content;

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Mass Spectrometry-Based Chemical Proteomics

technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section;

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Advances in Cancer Research

Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour;

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Label-Free Technologies For Drug Discovery

-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based;

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Riboswitch Discovery, Structure and Function

. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch;

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Progress in Medicinal Chemistry

. Despite the many advances in genetics, genomics and systems biology, 'validation' of a target is not achieved until therapeutic efficacy;

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Protein Analysis using Mass Spectrometry

for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives * Brings together the most;

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Systems Biology in Drug Discovery and Development

phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design;

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Model Organisms in Drug Discovery

industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that;

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Fragment-Based Drug Discovery

of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry;

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Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma

) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably;

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Pharmacology in Drug Discovery and Development

, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies;

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Small RNAs:

. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the;

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Small RNAs

. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the;

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Designing Multi-Target Drugs

discovery of multi-target drugs. It describes the current state of the art, the achievements and the challenges of the field and importantly the;

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Computational Chemogenomics

This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target;

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Proteomic and Metabolomic Approaches to Biomarker Discovery

and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery;

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Predictive Approaches in Drug Discovery and Development

Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and;

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Proteomics in Laboratory Medicine, An Issue of Clinics in Laboratory Medicine

Topics include: Development and Validation of Reverse Phase Protein Microarrays for Personalized Therapy, Imaging Mass Spectrometry for;

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