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This volume is the second part ofthe thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein;
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Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an;
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channels in health and disease, ion channels as therapeutic targets and the molecular pharmacology of ion channels. Provides a must;
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mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as;
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mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as;
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readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This;
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settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference;
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evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section;
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tumor markers of tomorrow - both for diagnostic and therapeutic purposes. As part of a three-volume collection, this book will fascinate;
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Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume;
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.). Furthermore, potassium ion channels may be a target protein for the research and development of a therapeutic agent for various diseases concerning;
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in disease states and their potential use as molecular targets for novel therapeutic agents.;
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Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and;
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Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and;
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Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage;
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, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion;
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and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and;
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used to study ion transport membrane proteins such as single-molecule spectroscopy * Details a wide range of electrophysiological techniques;
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, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid;
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as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many;
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of ligand-gated or voltage-gated ion channels. The use of broad classes of synthetic chemistries with common modes of action, along with the;
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inhibition or activation will render different therapeutic uses. Chapters cover specific biochemical targets like kinases, phosphatases;
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; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and;
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Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful;
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Ion Channels Part B, Volume 652 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting;
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and general mechanisms of sterol regulation of ion channels, the Regulation of ion channels by sterols as boundary lipids, the Differential;
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