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Inhibitors of Molecular Chaperones as Therapeutic Agents

research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a;

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Molecular Chaperones and Cell Signalling

reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting;

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Molecular Chaperones and Cell Signalling

reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting;

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The Biology of Extracellular Molecular Chaperones

in various chronic diseases and their potential as preventative or therapeutic agents. The Biology of Extracellular Molecular Chaperones;

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Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic;

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Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy;

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Chaperones

This volume is a compilation of laboratory protocols and methodology required for the study of molecular chaperones and the cellular stress;

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Molecular Chaperones of the Endoplasmic Reticulum

chaperones operate in the endoplasmic reticulum to assist protein folding. This book reviews our current knowledge of molecular chaperones of the;

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Protein Chaperones and Protection from Neurodegenerative Diseases

The intersection of molecular chaperones and neurodegeneration is an intensely studied area because of the potential of manipulating the;

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New Research on Molecular Chaperones

conditions, as well as an overview of studies focusing on molecular chaperones as potential targets for designing novel anti-parasitic drugs, are;

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Protein Misfolding in Neurodegenerative Diseases

, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel;

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Protein Misfolding in Neurodegenerative Diseases

, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel;

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Chemotherapy for Leukemia

. This improvement has been made possible with the development of molecular targeted agents such as bcr-abl tyrosine kinase inhibitors and all;

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Hypercoagulable States and New Anticoagulants, An Issue of Hematology/Oncology Clinics of North America

This issue addresses hypercoagulable states, such as antiphospholipid antibody syndrome, cancer-associated thrombosis, and coagulopathy;

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Small-molecule Transcription Factor Inhibitors in Oncology

allow tumour cells to be reprogrammed , leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors;

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Molecular Chaperones

, Molecular Chaperones: Methods and Protocols serves as an ideal guide for all scientists who wish to pursue this vital biological action and its;

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Molecular Chaperones

, Molecular Chaperones: Methods and Protocols serves as an ideal guide for all scientists who wish to pursue this vital biological action and its;

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Molecular Chaperones in Human Disorders

Molecular Chaperones in Human Disorders, Volume 114 in the Advances in Protein Chemistry and Structural Biology series, provides an;

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Targeted Therapies in Cancer

century has seen the emergence of targeted therapy, resulting from the identification of molecular pathways in cells and their alterations;

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Cyclic Nucleotide Phosphodiesterases in Health and Disease

inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE;

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Cancer Inhibitors from Chinese Natural Medicines

Nature is an attractive source of therapeutic and preventive compounds, and with such chemical diversity found in millions of species;

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Handbook of Molecular Chaperones

Molecular chaperones are a ubiquitous class of proteins that play important roles in protein folding and in the protection of cells from;

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A Closer Look at Kinase Inhibition

, DYRK1A, CDK5, GSK3 and CK1, are analyzed as data indicate that targeting these proteins may have therapeutic promise against Alzheimer's disease.;

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre;

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Type III Secretion Chaperones

. Unlike traditional molecular chaperones, these specialised type III chaperon do not assist in protein folding and are not energised by ATP;

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Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC;

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Uptake and Trafficking of Protein Toxins

of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins' translocation;

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