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Modern Dose Finding Designs for Cancer Phase I Trials Drug Combinations and Mol

adaptive dose-finding methods in drug developments are also provided.;

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Dose Finding in Drug Development

is a summary of results obtained from many scientific experiments. The book introduces the drug development process, the design and the;

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Statistical Methods for Dose-Finding Experiments

Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods;

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Dose Finding by the Continual Reassessment Method

As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to;

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An Introduction to Dose-Finding Methods in Early Phase Clinical Trials

, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding;

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Dose Optimization in Drug Development

, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical;

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Handbook of Methods for Designing, Monitoring, and Analyzing DoseFinding Trials Chapman HallCRC Handbooks of Modern Statistical Methods

than that of early phase studies. The need to accelerate drug development in a rapidly evolving context of targeted therapies, immunotherapy;

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Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R

for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for;

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Formulation and Analytical Development for Low-Dose Oral Drug Products

There are unique challenges in the formulation, manufacture, analytical chemistry, and regulatory requirements of low-dose drugs. This book;

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Statistical Methods in Drug Combination Studies

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical;

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Statistical Methods in Drug Combination Studies

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical;

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Drug Synergism and Dose-Effect Data Analysis

conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need;

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Drug Synergism and Dose-Effect Data Analysis

conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need;

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Prescribing for Elderly Patients

A guide for doctors to quickly choose the right drugs in the right dose for the most important clinical problems in the elderly Prescribing;

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Preclinical Development Handbook

need to be considered when developing a new drug. The book details steps in the preclinical process including: prioritizing and optimizing;

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Clinical Pharmacokinetics

. Pharmacokinetics is the study of the process of drug absorption, distribution, metabolism and elimination. The aim of applying pharmacokinetic principles;

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Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry;

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Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry;

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Epigenetic Targets in Drug Discovery

epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.;

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Statistical Methods in Biomarker and Early Clinical Development

This contributed volume offers a much-needed overview of the statistical methods in early clinical drug and biomarker development. Chapters;

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Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development

Complex Diseases 5 Finding Innovative Ways to Integrate Genetic Research into the Drug Development Process 6 Reflecting Back and Looking;

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Computational Drug Discovery for Vibrio cholera

have been a boon to the drug discovery activity. It will help in reducing the cost of novel drug development. In the current book on;

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Clinical Pharmacokinetics

, namely, multiple or (sub) chronic administration. In day to day practice besides acute drug response, often a longer duration of action;

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Novel Drug Delivery Technologies

products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and;

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Cancer

The development of drug-resistant cancers is considered to be the most significant obstacle to the cure of cancer today. Nearly half of all;

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Cancer

The development of drug-resistant cancers is considered to be the most significant obstacle to the cure of cancer today. Nearly half of all;

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Bioequivalence and Statistics in Clinical Pharmacology

studies are performed as part of drug development; and demonstrates the proposed methods using real world examples. Drawing on knowledge gained;

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