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DNA-targeting Molecules as Therapeutic Agents

examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide-DNA;

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DNA-binding aromatic drug molecules

Aromatic molecules have been widely utilized in medicine as components of therapeutic drugs effective against various diseases. Of utmost;

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Antibacterial Agents

bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell;

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Antibacterial Agents

bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell;

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Diabetic Retinopathy

because trial data does not clearly define the best option. Emerging therapeutic areas are evaluated, as work continues to identify agents that;

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Untangling the Double Helix

helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled;

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Untangling the Double Helix

helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled;

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Dna Nanotechnology For Bioanalysis

-canonical DNA structures (such as G-quadruplexes) and their targeting by small molecules for applications in pharmacology. Finally, it describes the;

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DNA Repair

adaptive function of sex in bacteria and eukaryotes; DNA repair as a therapeutic target in breast cancer; DNA repair in the nervous system;

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Advances in DNA Sequence-Specific Agents

interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well;

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Biomedical Aspects of Drug Targeting

Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results;

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Biomedical Aspects of Drug Targeting

Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results;

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Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA;

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Cancer Drug Design and Discovery

advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf;

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Apoptosis: Modern Insights Into Disease from Molecules to Man

Targeting the key active elements in the mechanism and application of apoptosis and its therapeutic implications, Apoptosis;

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Protein Degradation with New Chemical Modalities

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a;

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Prognostic & Predictive Response Therapy Factors in Cancer Disease

, thus sparing normal tissues. Those molecules are called biomarkers, and their identification is recommended for correct therapeutic planning;

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Development of Selective DNA Interacting Ligands

molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural;

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Development of Selective DNA Interacting Ligands

molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural;

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Organelle and Molecular Targeting

the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are;

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Polymeric Nanomaterials in Nanotherapeutics

drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy tissues and cells. The;

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Horizons in Cancer Research

pathogenesis and molecular targeting strategies for therapeutic options; rectal cancer staging; new DNA intercalating anti-cancer drugs; protection;

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Targeted Therapies in Cancer

in tumors. An increasing number of compounds targeting specific molecules or cancer cells have been developed and, for some of them, approved by the;

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Advances in Eicosanoid Research

been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as pro;

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Nanostructures and Nanoconstructions based on DNA

, nucleic acid-based molecules are primary candidates as building blocks for development of nanoscale systems and devices. Written for;

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Nanostructures and Nanoconstructions based on DNA

, nucleic acid-based molecules are primary candidates as building blocks for development of nanoscale systems and devices. Written for;

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Protein Targeting with Small Molecules

of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors* Reviews;

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