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Biophysical Approaches Determining Ligand Binding to Biomolecular Targets

The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the;

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Reversible Ligand Binding

biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field;

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Applied Biophysics for Drug Discovery

not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: Design considerations in biophysical;

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Computer Aided Drug Design

simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential;

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Biomolecular Sensors

monitor vital biological interactions-such as the binding of DNA to proteins-in real time, deriving unique information necessary to understanding;

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Ligand Binding in the Transmembrane Region

Ligand Binding in the Transmembrane Region is een boek van Tobias Noeske;

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Quantitative Characterization of Ligand Binding

The book fills the void between rigorous theoretical discussions of ligand binding for physical chemists (often beyond the needs of bench;

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Pseudokinases

signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases;

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Regulation Of G Protein Coupled Receptor Function And Expression

, arrestins) in modulating receptor function; and the methods used to measure receptor trafficking (ligand binding, immunofluoresence) and expression;

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Computational Approaches to Nuclear Receptors

safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these;

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Vitamin Receptors

vitamin ligand to a protein and its sequela. The various groups of vitamin-binding proteins are particularly significant as they relate to the;

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Molecular Chemistry and Biomolecular Engineering

chemistry with biomolecular engineering, with the goal of creating new biological or physical properties to address scientific or societal;

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Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all;

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Biomolecular and Bioanalytical Techniques

An essential guide to biomolecular and bioanalytical techniques and their applications Biomolecular and Bioanalytical Techniques offers;

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Protein Interactions as Targets in Drug Discovery

fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein;

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Protein-Ligand Interactions

is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones;

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Ions in Water and Biophysical Implications

Over the past decade, numerous books have attempted to explain ions in aqueous solutions in relation to biophysical phenomena. Ions;

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Innovations and Implementations of Computer Aided Drug Discovery Strategies in R

mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing;

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Ligand-Receptor Energetics

of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and;

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Surface Plasmon Resonance

experiment is simple: There is a sensor surface to which one of the interacting partners (the ligand) is immobilized; the other partner (the analyte;

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Methods for fragments screening using Surface Plasmon Resonance

and presents methods to calculate equilibrium dissociation constant (KD) and ligand efficiency (LE). It reviews techniques of next-generation;

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Surface Plasmon Resonance

labelling methods, in terms of: 1) ligand-analyte binding kinetics, that can be probed without the costly and time-consuming labeling process that;

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Molecular Methods in Plant Pathology

will find this a useful reference on biophysical, biochemical, biomolecular, and biotechnological methods.;

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Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B

practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion;

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Biomolecular Kinetics

practice. -Michael Geeves, University of Kent covers the entire spectrum of approaches, from the traditional steady state methods to a;

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Biomolecular Kinetics

. -Michael Geeves, University of Kent covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account;

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Statistical Physics of Biomolecules

From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and;

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