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. An Introduction to Statistics in Early Phase Trialsdescribes the practical design and analysis of these importantearly phase clinical trials;
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This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will;
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agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping;
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agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping;
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years ahead. With this goal in mind we present: An introduction to the field for graduate students and novices A basis;
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of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new;
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, researchers, and practitioners * An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human;
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properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical;
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learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners;
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. It focuses on the statistical analyses most commonly used in drug development and is therefore an ideal introduction to pharmaceutical;
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may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it;
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may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it;
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Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview;
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phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an;
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phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an;
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of Phase I/II Clinical Drug Trials is that source. It is an indispensable guide, readily providing the information needed to make crucial decisions;
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-to-day clinical pharmacology work. The book is a starting point for those involved in such research and covers the methods needed to design;
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-to-day clinical pharmacology work. The book is a starting point for those involved in such research and covers the methods needed to design;
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The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review;
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The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review;
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trials. This new edition is updated throughout and includes five new chapters. Developed from the authors' courses taught to public health and;
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. Developed from the authors' courses taught to public health and medical students, residents, and fellows during the past 15 years, the text shows;
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programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving;
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Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating;
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practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and;
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wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by;
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each therapy area. It also presents: A history of clinical trials A summary of pertinent statistical issues How to choose a clinical trial;
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